Matthew Wise, M.D.
Certified Doctor of Venous & Lymphatic Medicine



Specializing in vein treatments in Orange County, CA.

Conditions Treated




What We Offer
Microphlebectomy, also known as stab avulsion or ambulatory phlebectomy, is a minimally invasive treatment to remove varicose veins through tiny incisions in the skin. The incisions are so small they do not require stitches and are performed with local anesthetic only. The entire procedure can be performed in the doctor’s office. Patients can drive themselves home and resume normal activities the next day. Dr. Hoyle pioneered the use of microphlebectomy in Southern California after receiving training in Switzerland 20 years ago.
A treatment in which a traditional sclerotherapy solution is rapidly mixed and aerated to create a foam that is injected into the veins. An ultrasound machine is used to visualize and gain access to the abnormal veins with a tiny needle through which the foam sclerosant is injected. The foam closes off and seals the varicose veins. Generally, this form of sclerotherapy works better for larger abnormal veins because the amount of foam can be altered based on the size of the vein.
Varithena™ is an injectable foam treatment for varicose veins. The microfoam medication fills the inside of the damaged vein, causing it to collapse and seal itself closed. Blood is then forced to flow through healthier veins. This is an effective treatment for several types of vein problems of all sizes, both above and below the knee. Varithena™ is also suitable to retreat veins that didn’t respond to other therapies, and it’s a suitable treatment for patients who have issues with the great saphenous vein.
Microneedling involves using fine needles to create hundreds of tiny, invisible puncture wounds in the top layer of skin. This minimally invasive treatment can be very effective. The micro-injuries stimulate the body’s natural wound healing processes, resulting in cell turnover and increased collagen and elastin production, therefore reversing as well as preventing signs of aging. In fact, according to a 2009 study, almost 100% of micro-needling participants reported a noticeable difference and vast improvement in the appearance of their acne scars after treatment.
Endovenous Laser & Radiofrequency Ablation (EVLA) is a minimally-invasive procedure commonly used to treat varicose veins resulting from chronic venous insufficiency. During the procedure the doctor creates a tiny cut in the skin to insert a laser fiber into the diseased vein. He numbs the area with local anesthetic then activates the laser. As he withdraws the laser the vein collapses and is sealed. The body is then able to re-direct blood flow through healthy veins.
VenaSeal™ is an injectable treatment for varicose veins. Unlike other treatments, VenaSeal™ doesn’t use heat or a foaming sclerosant medication to close damaged veins. Instead, it uses an adhesive substance to help varicose veins close and stay shut. During the procedure, Dr. Hoyle makes a small puncture in the leg and guides a catheter into the diseased vein. Then, while slowly withdrawing the catheter, he injects the adhesive substance into the varicose vein. Pressure is then applied to the vein to help it close and seal itself.
Patients who have been diagnosed with restless leg, diabetic neuropathy, or other conditions who are not showing improvement with treatment may want to seek a second opinion. With these and other venous conditions, the symptoms are often very similar and a misdiagnosis can extend the time that a patient suffers from a painful condition. If patients from Orange County or the greater Los Angeles area are concerned that their treatment is not as effective as it could be, they should make an appointment with Advanced Vein Center. Our doctors are truly experts in their field and are among the leading physicians treating venous conditions in the United States.
Our doctors conduct thorough assessments to determine whether a patient’s symptoms are actually caused by varicose veins versus another condition. For example, many patients who have venous disease also have arthritis and back problems with sciatica. This means their pain may be a result of these other conditions and not associated with their varicose veins. At Advanced Vein Center we will never perform a treatment unless we know for certain it is the right approach for a patient’s symptoms.

Advanced Vein Center
Vein Specialists located in Orange, CA
Advanced Vein Center was founded by California’s leading experts and pioneers in the field of Phlebology (the specialty of vein disorders). For over 15 years, we have been delivering patients superior results while saving them thousands in treatment costs. All of our doctors are certified by the American Venous and Lymphatic Society as specialists in the treatment of venous disease. Advanced Vein Center is a renowned vein treatment center in Southern California specializing exclusively in the diagnosis and treatment of venous disorders including spider veins and varicose veins.
What Makes Us Different
Experience ♦ Ethics ♦ Results
When you trust your care to Advanced Vein Center you can feel comfortable in the confidence that your treatment is being at one of the most respected and ethical clinics in Southern California. All our procedures are done in our office on an outpatient basis with the use of local anesthetic and mild sedative if needed. This saves our patients thousands of dollars on expensive hospital bills. The patient is awake throughout the procedure and able to resume normal activity almost immediately.
Advanced Technology and Techniques
Explicit Diagnosis
Diagnostic Ultrasound is now considered the standard of care for evaluating vein disorders in the lower legs. Treatment failures for spiders and bulging veins are often due to overlooking problems with deeper veins in the legs. Only ultrasound can see these problems. If the test is ordered and performed at a hospital or outpatient diagnostic center, it is often done by a technologist who has had minimal or no training in evaluating the superficial veins. We perform diagnostic ultrasound exams in our office using state of the art ultrasound equipment dedicated explicitly to vein evaluations. We do not refer our patients to an outside imaging center or hospital for ultrasound evaluation. We have found too often that outside sonographers are not properly trained in evaluating the superficial veins.
Veinlite’s cutting edge technology facilitates better visualization of deeper and feeder veins. By targeting the veins that feed spider veins, we can dramatically improve the results of treatment. The larger area of illumination also speeds up vein location allowing us to treat more veins in a shorter period of time.
The Syris V600 is state-of-the art device that amplifies the appearance of veins underneath the skin. Using cross polarization technology, it allows the physician to literally see venous structure through the superficial skin layers. This yields improved accuracy and and the best results possible from treatment.
Endovenous laser treatment has continued to evolve over the last decade. The original lasers were in the 800 to 100 nm wavelength and targeted hemoglobin part of blood. The newest lasers are in the 1400 nm range and target the water part of blood. This allows treatment with 1/3 of the energy previously needed and results in none to minimal bruising and discomfort.
Pro-Nox allows patients full control in managing their pain and anxiety during a procedure. This self-administered system delivers a 50/50 blend of oxygen nitrous oxide that takes effect in seconds and is cleared from the body in minutes. It has been proven safe & effective over decades of use in various clinical settings.
Advanced Vein Center is pleased to offer patients and clients flexible payment options including:
- Most PPO insurances accepted
- Medicare
- Care Credit Financing Program Available
- Credit Cards Accepted: Visa, Master Card and Discover
- Please contact the office for complete coverage details and questions
















Words From Our Patients

“My mother began seeking treatment from Advanced Vein Center and has been very happy with her results!”

“I went to Dr. Hoyle and Advanced Vein Center for a second opinion after going to West Coast Medical where they wanted to perform 4 separate surgery’s where I would be put under and would not be able to drive myself home after. Dr. Hoyle performed my procedure in 30 minutes in the office and I was able to drive myself home. Dr. Hoyle is excellent in his field.”

“I have had varicose veins since I was 13 and in my 40s finally got them taken care of. Advanced Vein Center did a wonderful job. I can now hike pain free. I saw another Dr. prior and he was horrible. Dr. Hoyle was professional and fixed my veins. The office staff is nice and I never had to wait for my appointments. Very good experience and I recommend the happy pill pack prior to procedures. I did one procedure without and then with and I felt much better with. I am a wimp when it comes to medical procedures.”

“Dr. Hoyle is a great doctor! He is very thorough and made sure he resolved all my concerns. I highly recommend Advanced Vein Center!”

“Everyone at Advanced Vein Center is professional and informative, I was impressed with all the personal attention I received.”

“I have never had vein problem until about 6 months ago so once I did find out, I immediately asked various doctor friends of mine for recommendations. In each case without exception, Advanced Vein Center and was the recommendation. The Doctor was amazing and I cannot give his and his office enough praise. The work done on my two legs was fast, done in the office and totally pain free”
“I am very happy with the treatment I’ve received at Advanced Vein Center. The staff is super friendly and helpful, and couldn’t be more skilled at identifying the various vein issues that I’ve had. When I came to this office I was having some pain, large bulging varicose veins that were becoming more numerous as years were going on. AVC has helped to close veins on both legs, using a couple of different techniques. His procedures have reduced the pain and the entire look of my legs. Additionally, he is helping to remove the spider veins and dark spots. My legs are no longer bumpy and with dark spots. I feel very fortunate to have found such a wonderful facility. I will continue to return as the need arises.”

“Dr. Hoyle and his staff are very knowledgeable about venous insufficiency and have helped me tremendously in my treatment. I’ve been suffering for a few years now searching for the right Doctor who knew how to help me. So happy I found Advanced Vein Center, in fact I’ve referred a couple of family members with the same issues and they’re just as satisfied with their results as I am, thank you again everyone at AVC, you’re the best!”

“I give the highest praises, and heart-felt recommendation, to Advanced Vein Center and the staff. I give them 5 out of 5 stars for: professionalism, kindness, expertise, and pain-free and effective treatment of the veins in my legs.”
“My mom has suffered from the tiredness and discomfort of varicose veins for many years. Lately she couldn’t tolerate standing for a long time or even enjoy her daily activities. Thankfully I came across Advanced Vein Center and Dr.Wise has done an amazing job. She underwent surgery for one leg in August and the results were so great that she came back in September to get surgery on her other leg. Dr. Wise is so knowledgeable and patiently explained the procedures. I felt comfortable with Dr. Wise and knew that my mom was in great hands. The staff is also caring & kind. Both Jackie & Lisa made us feel welcomed from the beginning. I highly recommend Dr. Wise at Advanced Vein Center.”