Conditions Treated

Spider veins occur when tiny veins dilate below the surface of the skin, causing red, blue or purple discolorations. They are most common on the thighs, ankles and calves, and are more common in women than men. Spider veins are also more common with age – by age 70, approximately 70% of the population will be affected. The cause isn’t completely understood in every case, but heredity plays a major role. Some cases are related to pregnancy, use of birth control pills or weight gain. People whose work requires them to stand for long periods of time are also at higher risk.
Varicose veins are large, swollen, twisted veins, dark blue or purple in color, that often appear on the legs and feet. They occur when the valves in the veins do not work properly, so the blood does not flow effectively. In some cases it is only an aesthetic concern. However, many people experience painful symptoms such as swelling, throbbing, burning, itching, cramping, or a heavy, achy feeling in the legs or feet. In some cases, patients experiencing these symptoms may not have any visible varicose veins. The diseased veins can occur deep under the skin, invisible to the naked eye.
Varicose Veins
A venous ulcer is an open sore that occurs on the legs when blood is not being pushed back to the heart the way it should. Blood remains in the veins, resulting in pressure buildup inside. The liquid part of blood is pushed out of the vein causing edema (swelling) and poor tissue nutrition. When left untreated, the excess fluid causes the skin to break and an open sore forms. The ulcer often can become infected and require frequent visits to a doctor’s office. Ulcers are usually preceded by leg swelling and skin changes such as a redness and a thickening of the skin.
Venous Leg Ulcer
At Advanced Vein Center, we have expertise in treating veins on more than just the legs. We can also treat veins on the hands and other parts of the body. On the hands, veins are usually not diseased but can become more visible as the skin relaxes and thins with age. They can be easily injured as the skin becomes more fragile. We offer a number of highly effective treatments for these and other types of visible veins.

What We Offer

Microphlebectomy, also known as stab avulsion or ambulatory phlebectomy, is a minimally invasive treatment to remove varicose veins through tiny incisions in the skin. The incisions are so small they do not require stitches and are performed with local anesthetic only. The entire procedure can be performed in the doctor’s office. Patients can drive themselves home and resume normal activities the next day. Dr. Hoyle pioneered the use of microphlebectomy in Southern California after receiving training in Switzerland 20 years ago.

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A treatment in which a traditional sclerotherapy solution is rapidly mixed and aerated to create a foam that is injected into the veins. An ultrasound machine is used to visualize and gain access to the abnormal veins with a tiny needle through which the foam sclerosant is injected. The foam closes off and seals the varicose veins. Generally, this form of sclerotherapy works better for larger abnormal veins because the amount of foam can be altered based on the size of the vein.

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Varithena™ is an injectable foam treatment for varicose veins. The microfoam medication fills the inside of the damaged vein, causing it to collapse and seal itself closed. Blood is then forced to flow through healthier veins. This is an effective treatment for several types of vein problems of all sizes, both above and below the knee. Varithena™ is also suitable to retreat veins that didn’t respond to other therapies, and it’s a suitable treatment for patients who have issues with the great saphenous vein.

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Microneedling involves using fine needles to create hundreds of tiny, invisible puncture wounds in the top layer of skin. This minimally invasive treatment can be very effective. The micro-injuries stimulate the body’s natural wound healing processes, resulting in cell turnover and increased collagen and elastin production, therefore reversing as well as preventing signs of aging. In fact, according to a 2009 study, almost 100% of micro-needling participants reported a noticeable difference and vast improvement in the appearance of their acne scars after treatment.

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Endovenous Laser & Radiofrequency Ablation (EVLA) is a minimally-invasive procedure commonly used to treat varicose veins resulting from chronic venous insufficiency. During the procedure the doctor creates a tiny cut in the skin to insert a laser fiber into the diseased vein. He numbs the area with local anesthetic then activates the laser. As he withdraws the laser the vein collapses and is sealed. The body is then able to re-direct blood flow through healthy veins.

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VenaSeal™ is an injectable treatment for varicose veins. Unlike other treatments, VenaSeal™ doesn’t use heat or a foaming sclerosant medication to close damaged veins. Instead, it uses an adhesive substance to help varicose veins close and stay shut. During the procedure, Dr. Hoyle makes a small puncture in the leg and guides a catheter into the diseased vein. Then, while slowly withdrawing the catheter, he injects the adhesive substance into the varicose vein. Pressure is then applied to the vein to help it close and seal itself.

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Patients who have been diagnosed with restless leg, diabetic neuropathy, or other conditions who are not showing improvement with treatment may want to seek a second opinion. With these and other venous conditions, the symptoms are often very similar and a misdiagnosis can extend the time that a patient suffers from a painful condition. If patients from Orange County or the greater Los Angeles area are concerned that their treatment is not as effective as it could be, they should make an appointment with Advanced Vein Center. Our doctors are truly experts in their field and are among the leading physicians treating venous conditions in the United States.

Our doctors conduct thorough assessments to determine whether a patient’s symptoms are actually caused by varicose veins versus another condition. For example, many patients who have venous disease also have arthritis and back problems with sciatica. This means their pain may be a result of these other conditions and not associated with their varicose veins. At Advanced Vein Center we will never perform a treatment unless we know for certain it is the right approach for a patient’s symptoms.

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Advanced Vein Center

Vein Specialists located in Orange, CA

Advanced Vein Center was founded by California’s leading experts and pioneers in the field of Phlebology (the specialty of vein disorders). For over 15 years, we have been delivering patients superior results while saving them thousands in treatment costs. All of our doctors are certified by the American Venous and Lymphatic Society as specialists in the treatment of venous disease. Advanced Vein Center is a renowned vein treatment center in Southern California specializing exclusively in the diagnosis and treatment of venous disorders including spider veins and varicose veins.


What Makes Us Different

Experience Ethics Results

When you trust your care to Advanced Vein Center you can feel comfortable in the confidence that your treatment is being at one of the most respected and ethical clinics in Southern California. All our procedures are done in our office on an outpatient basis with the use of local anesthetic and mild sedative if needed. This saves our patients thousands of dollars on expensive hospital bills. The patient is awake throughout the procedure and able to resume normal activity almost immediately.

Advanced Technology and Techniques

Explicit Diagnosis
Diagnostic Ultrasound is now considered the standard of care for evaluating vein disorders in the lower legs. Treatment failures for spiders and bulging veins are often due to overlooking problems with deeper veins in the legs. Only ultrasound can see these problems. If the test is ordered and performed at a hospital or outpatient diagnostic center, it is often done by a technologist who has had minimal or no training in evaluating the superficial veins. We perform diagnostic ultrasound exams in our office using state of the art ultrasound equipment dedicated explicitly to vein evaluations. We do not refer our patients to an outside imaging center or hospital for ultrasound evaluation. We have found too often that outside sonographers are not properly trained in evaluating the superficial veins.

Veinlite’s cutting edge technology facilitates better visualization of deeper and feeder veins. By targeting the veins that feed spider veins, we can dramatically improve the results of treatment. The larger area of illumination also speeds up vein location allowing us to treat more veins in a shorter period of time.

The Syris V600 is state-of-the art device that amplifies the appearance of veins underneath the skin. Using cross polarization technology, it allows the physician to literally see venous structure through the superficial skin layers. This yields improved accuracy and and the best results possible from treatment.

Endovenous laser treatment has continued to evolve over the last decade. The original lasers were in the 800 to 100 nm wavelength and targeted hemoglobin part of blood. The newest lasers are in the 1400 nm range and target the water part of blood. This allows treatment with 1/3 of the energy previously needed and results in none to minimal bruising and discomfort.

Pro-Nox allows patients full control in managing their pain and anxiety during a procedure. This self-administered system delivers a 50/50 blend of oxygen nitrous oxide that takes effect in seconds and is cleared from the body in minutes. It has been proven safe & effective over decades of use in various clinical settings.

Advanced Vein Center is pleased to offer patients and clients flexible payment options including:

  • Most PPO insurances accepted
  • Medicare
  • Care Credit Financing Program Available
  • Credit Cards Accepted: Visa, Master Card and Discover
  • Please contact the office for complete coverage details and questions


Better doctors get the Best results!


based on 62 Google reviews

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based on 64 reviews

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based on 5 opinions

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Jocelyn W

There’s a reason Dr. Wise and staff consistently receive 5-star reviews – they check the box on many elements: knowledge, skill, professionalism, and care. Each patient is treated more like a family member rather than just a number and is cared for with kindness. Dr. Wise is incredibly knowledgable and takes the time to walk you through the details so you know exactly what is happening and what you can expect. I’m so glad I finally found my go-to place to treat my vein issues that I have been battling for the past decade. I had some issues with my insurance and their team did an excellent job trouble shooting the process from A to Z. Who does this? Thank you Dr. Wise, Jackie and Sergio!

Tonya M

Thank you to Dr. Wise and the entire staff at Advanced Vein Center. I am so happy I came here after years of suffering from annoying ugly spider veins. I can’t believe how great the results are after just a few months. Dr. Wise is incredibly knowledgeable and he takes the time to walk you through the details while answering all your questions so you know exactly what to expect. He is generous with his time as well and makes sure you are happy at the end of your session. I couldn’t be more thankful for the kind treatment and such great results. The staff makes the office so nice to visit, especially Jackie. She is so personable and kind and always has a smile. Can’t forget Sergio, he is always helpful and kind. If you are struggling with spider veins I would highly recommend this place!

Georgia P

The doctor is so personable and my leg is feeling so much better. They answer the phone on the first ring and I never had to wait for my appointment for n the office, they took me right in. The also worked with my complicated insurance effortlessly. If I had known it would be this easy I wouldn’t have waited so long to get started.

Kelly D

I am EXTREMELY scared of veins and needles, my phobia is very real and I always have a panic attack dealing with anything involving needles. EVERYONE at this office has been incredibly kind and thorough. I can’t say enough about how much I love the staff and Dr Wise. The results are amazing and I would recommend them!

Mellie B

Overall very happy with my results and with this office! The staff is friendly and nice. Dr Wise was personable and had great bedside manner. He explained everything to me and answered all of my questions. Price is very fair. Great office if you have vein issues!!!

Denise V

The staff at Advanced Vein is the kindest I’ve ever experienced in a medical environment.  
Dr Wise explained my procedures thoroughly and reassuringly. Sergio was understanding, gentle, and knowledgeable regarding my leg sensitivity and took great care when performing my ultrasound exams. All personnel are calm and efficient and treated me with excellence. I’ve had four or five visits there so far. Parking is free, easy and office is on the ground floor.

Laura R

I’m very satisfied with the results. My spider veins contributed to my hesitancy in wearing shorts. But, after getting treatment at Advance Vein Center my spider veins have dramatically faded away. You do have to be patient to see the results since right after treatment your veins are irritated. Everyone is very professional. The doctor took time in explaining the procedures which I really appreciate.

Favi M

Excellent place! Great staff! I have been suffering with varicose veins since I was sixteen years old. I couldn’t wear shorts or even capri pants because I felt embarrassed of the way my legs looked. Aside from the cosmetic issues, the vein pain discomfort and the swelling was the worst part for me. I started looking online for many places and found advanced vein center. I am so glad I did. Dr. Wise, Layla, Jackie, and Sergio made me feel very welcomed for every appointment. I never felt rushed and Dr. Wise always took his time to listen to me. I can feel and see a difference in my legs. Very thankful!

Tammy P

Dr Wise and staff are very knowledgeable and excellent caregivers. They are concerned with not only how you feel as a patient, but also with your general health and well being. While having a procedure done, they make sure you feel comfortable and calm. I’ve already recommended them to several of my friends.

Jenna D

I don’t think I’ve ever left a Google Review before but I really needed to with Advanced Vein. If you are considering getting vein care in OC, I cannot recommend this place enough. From the second I walked into their office, I felt welcomed and in good hands. Everyone there is so knowledgeable and friendly. Dealing with vein issues can feel overwhelming and so stressful initially. The professionalism and genuine care everyone provided has been amazing. Dr. Wise never made me feel rushed in the consultation, he answered any question that I had with patience and attentiveness, went over in detail how sclerotherapy works and its (minor) risks – all of which set me up for a realistic expectation on positive end results. I feel so comfortable and optimistic getting care here. I still have 1 or 2 treatments to go but I am already already feeling (and looking) so much better. I can’t recommend this center enough. Thank you Dr. Wise + wonderful team! 😊


This is absolutely the only place you need to go to treat your varicose veins. The whole team of Dr. Wise, Sergio, and Jackie is top-notch. Dr. Wise is knowledgeable, caring, skillful, and very flexible (can get your treatment started in a few days). Sergio is meticulous and methodical with Ultrasound scan (this is actually super important in order to identify the root problem of varicose veins and come up with the right treatment plans). Jackie is the ultimate scheduling master. My legs are looking so much better now. My only regret was that I had not started the treatment with them earlier.

Mercedes L

I am writing this review on behalf of my mom. She had been suffering from varicose veins for many years due to standing long hours for work. Her ankles were throbbing and in so much pain. She went to Advanced Vein Center for a 2nd opinion due to a very bad experience with another doctor. She was immediately put at ease when she met the Dr. Wise and his team. They were all so kind and informative. She is currently being treated by Dr. Wise & is so happy to be in his care. The relief she felt was immediate. We are so thankful for them!

Nga D

For years I have had varicose veins, and they are definitely not attractive or comfortable to have. Multiple times, vein specialists prescribed compression stockings, but they didn’t work. As I age, the varicose veins gotten worsen. The next step was to treat it surgically. I consulted a vein specialist at Hoag’s Hospital, but I never got to the procedure due to covid pandemic shutdown. A few months when the pandemic improves, I decided to seek treatment again with Advanced Vein Center. Dr. Wise and his staff (especially Jackie) were amazing. They were friendly and professional so I am very satisfied with my experience. After several visits, I notice an amazing transformation on my varicose veins. I highly recommend Advanced Vein Center for your treatment.

Sarah G

Haven’t had my veins treated in over 10 yrs. So there was a lot of work to be done. Everyone in the office was friendly. Dr. Wise was very good at explaining everything. Dr. Wise worked quickly to utilize every min that I paid for and I appreciated that. After one week I was almost completely healed and most of my veins had disappeared. I have one more appointment and then my legs should be ready for the summer! Thanks to AVC.

Denise V

The staff at Advanced Vein is the kindest I’ve ever experienced in a medical environment.  
Dr Wise explained my procedures thoroughly and reassuringly. Sergio was understanding, gentle, and knowledgeable regarding my leg sensitivity and took great care when performing my ultrasound exams. All personnel are calm and efficient and treated me with excellence. I’ve had four or five visits there so far. Parking is free, easy and office is on the ground floor.

Zoya S

I was referred to Dr. Wise by my daughter. Dr. Wise and his staff have been very professional and attentive to my needs. They listened to my concerns and answered all questions. Dr. Wise explained everything in great detail and recommended combination of 5 procedures. I had the producers done within 1,5 months and I am very pleased with the results. All procedures were painless and recovery was pretty quick. My legs look healthy now and varicose veins are hardly visible. I highly recommend Dr. Wise and his team for your vein needs.

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